Both sides have endured numerous revivals, collapses, peaks and troughs since – and yet find themselves roughly in the same position with inconsistency impacting their hopes of qualifying for the Champions League.
With both fourth-placed Arsenal and sixth-placed West Ham in action a day later, a win for either United or Tottenham will catapult them into the prime position to chase down the Gunners.
All eyes at Carrington will be on Cristiano Ronaldo after the striker flew home to Portugal having picked up an injury ahead of the Manchester derby.
Ralf Rangnick has confirmed that both Ronaldo and Edinson Cavani have returned to full training and will be available to face Spurs.
However, Scott McTominay is expected to miss out as United look to avoid making a calf injury worse.
Tottenham are without Ryan Sessegnon due to muscle issue ahead of the trip north. Sergio Reguilon is expected to come in at left wing-back.
Japhet Tanganga is also sidelined and Oliver Skipp will miss out with a groin injury.
Two teams who can look incredible one week then dismal the next. Predicting which Tottenham team will turn up is particularly difficult with Antonio Conte’s side as sublime against Everton as they were bad against Middlesbrough.
As for United, Rangnick has struggled to get his star-studded side to look threatening against even the meekest of teams.
Head to head (h2h) history and results
The away team has won each of their last three meetings.
Man United wins: 94
Tottenham wins: 53